Benadryl hallucination7/5/2023 ![]() ![]() Careful review of its use is necessary in this vulnerable population.ĪDVERSE DRUG reactions are a common iatrogenic complication in older hospitalized patients. Overall, 24% of diphenhydramine doses were administered inappropriately.Ĭonclusions Diphenhydramine administration in older hospitalized patients is associated with an increased risk of cognitive decline and other adverse effects with a dose-response relationship. A dose-response relationship was demonstrated for most adverse outcomes. Exposed patients also had increased risk for urinary catheter placement (RR, 2.5 95% CI, 1.0-6.0) and longer median length of stay (7 vs 6 days P =. The diphenhydramine-exposed group was at an increased risk for any delirium symptoms (relative risk, 1.7 95% confidence interval, 1.3-2.3) and for individual delirium symptoms, including inattention (RR, 3.0 95% CI, 1.5-5.9), disorganized speech (RR, 5.5 95% CI, 1.0-29.8), and altered consciousness (RR, 3.1 95% CI, 1.6-6.1). Results Of the 426 patients, 114 (27%) received diphenhydramine during hospitalization and shared similar baseline characteristics including age, sex, delirium risk, and Mini-Mental State Examination scores compared with nonexposed patients. Measurements included baseline and daily assessments including Mini-Mental State Examination scores, Confusion Assessment Method ratings, direct observations for medical devices (urinary catheter or physical restraints), and blinded medical record extractions for diphenhydramine use. Methods We enrolled 426 hospitalized medical patients aged 70 years or older in a prospective cohort study in a university hospital. Shared Decision Making and Communicationīackground Diphenhydramine hydrochloride is a commonly prescribed medicine in hospitalized patients, but its adverse effects on older patients remain unclear.Scientific Discovery and the Future of Medicine. ![]() Health Care Economics, Insurance, Payment.Clinical Implications of Basic Neuroscience.Challenges in Clinical Electrocardiography. ![]()
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